![]() Although there are some studies including the umbilical artery as a relevant vessel in the PE evaluation, traditionally this artery is taken together with the middle cerebral artery in the fetus status evaluation. Uterine artery is the most studied vessel in the Doppler evaluation in PE, because it represents the maternal vascular condition, through the pulsatility and resistance index (PI and RI respectively) and the presence of early diastolic notch (N). The latter has been considered a useful method for prediction of PE and adverse pregnancy outcome. The impaired placental perfusion caused by vascular abnormalities precedes clinical manifestations of PE and it can be detected by Doppler ultrasound (US). The pathophysiology of PE is based on the incapability of the trophoblast to invade properly the myometrium causing a limited remodeling of spiral arteries. The etiology of PE is still unknown, although an excessive maternal systemic inflammatory response and an imbalance between circulating angiogenic and anti-angiogenic factors have been described. PE affects 5-10% of pregnancies and is clinically manifested after 20 weeks of gestation (GW). Worldwide pre-eclampsia (PE) is the first cause of maternal mortality, intrauterine growth retardation (IUGR), and fetal prematurity. General Doppler US result, as well as N from uterine vessel, RI from umbilical artery, and PI from umbilical and middle cerebral arteries in their individual form, may be considered as tools to determine hemodynamic repercussion caused by PE. Other parameters like N presence, RI and PI of umbilical artery, as well as the PI of middle cerebral artery, showed differences between groups ( P values < 0.05). Abnormal general Doppler US profile showed a positive association with PE, and a specificity and predictive positive value of 89.2% and 88.6%, respectively. ![]() Blood velocity waveforms from uterine, umbilical, and middle cerebral arteries, in pregnancies from 24 to 37 weeks of gestation were recorded by trans-abdominal examination with a Toshiba Ultrasound Power Vision 6000 SSA-370A, with a 3.5 MHz convex transducer. ResultsĪ total of 102 pregnant Mexican women (65 PE women and 37 normotensive women) were recruited in a cases and controls study. The aim of this study was to evaluate the uterine, umbilical, and the middle cerebral arteries using Doppler US parameters in pregnant women, in order to make a global evaluation of hemodynamic repercussion caused by the established PE. Doppler Ultrasound (US) evaluation has been considered a useful method for prediction of PE however, there is no complete data about the most frequently altered US parameters in the pathology. ![]() PE is characterized by elevated blood pressure and proteinuria. Worldwide preeclampsia (PE) is the leading cause of maternal death and affects 5 to 8% of pregnant women.
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